The SinuCleanse Saline Packets contain 100% all - natural, preservative - free ingredients. Pharmaceutical grade, ultra-fine saline grains dissolve instantly in lukewarm water for ease, convenience and comfort when nasal washing. The SinuCleanse Saline Packets are safe and effective, even for people taking multiple medications or pregnant women. With absolutely no drug interactions, the SinuCleanse Saline Packets, make nasal washing stress - free and easy.